1951_forrer_1465_2.pdf

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M 360 Schizophrenia

M 377 Psychoses

I_RER, G.R. and GOIDNER_ R.D. (Ypsilanti, Mich.)

_rimental

_hvsiolo_ical

studies with _vserglc acid

amige

(ISD-2g).

Armh.Neurolo(Am.) 65,581(1951).

_X ISD No._

(_102a)

PROB_L_M: Investigation of the eff_ts of ISD in schizophrenic

patients.

METHOD_ Compiet_ pkvsical examirmtion, EEG, ECG, blood sugar,

NPN; WBC etc. BP, puiss and respiration determined every half

hour during a control period in which control stu&ies were

carried out with other _Ib_tances.

DOSAC_: ISD orally, 0.5-6.0 m_/kg body weight.

MATER!AL: 4 paranoid schizophrenic pats. : 2 _hebephrenic _+_.

RESULTS : LSD _roduced a slight rise in B.P_, msa_hmal_@Igh_

of r_sponse 2W hours after administration and return t_ normal

or 6 hours after administration. All changes in BP were with-

im normal physiological Limits. P_ls_ rate also incr_ase_ (with-

in physiological limits), extram_s being 100/mino and _8/mino

ISD produced constant flushing responses (duration and

rapidity of onset being related to dosag$, and increased saliva-

tion. Vomiting occurred only 3 times in 42 treatments° Dilation

of the pupils was regularly produced as were oonjunctival i_-

jecticn and increased lacrimation_ hFperactivity of deep re-

flexes, slight unsteadiness of gait but no disturbance of co-

ordination.

Slight rise in blood sugar levels 2-3 hours after ISD.

1 mg LSD/kg produced definite leucoc_tosis but no urinary changes

and no NPN changes. No effect on weight of the _ of the 6 pats,

one showed an increase of 9.1 kg. Direct instillation of ISD into

the conjunctival sac produced very little _ffeot on the pupils.

Thus pupillary dilation may be due primarily +_o central effects

and changes in EEG.

P_c_q

responses to ISD: Euphoria_ increased spon+_neous verbal

productivity, amiability, talkativeness,

outbursts of laughter,

after 0.5 mg ISD. These effects were greater and more prolonged

after 1-6 rag. Pats. always maintained relatively good contact

with their envir_mment. Hallucinations occurred in all pats. at

some time, their order of frequency being visual hallucinations_

parasthesias and various other somatic sensory disturbances. There

was increased accessiToility and spontaneity, which facilitated

production of psychic material. 2 blind pats. had no visual

hallucinations.

I mg atropine i.m., 4_ hours before 6 mg LSD produced

s_ght fl_shing on the skin in

all

pats° w_

moistening of the

mucous

membranes°

drying

effect noted°

Increase

deep

reflexes BeGan 112hours after 8dministration of ISD reaching a

ma_

2-2_ hours later° Response was irregular and varie_1frol

pati_t

topatient°

Little i_formation obtained on _bjective feelings _f pat_

It is believed t_hatLSD aots prlmarlly on t_ae cortex and that

the

neurological

_ptoms

following its administration are

directly attri_rata__ ÷,h_ _ortical effect and that the psychic

phennmema are the result_ of subcortical disohargeso

NKT/bh i151

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