1953_bradley_3957_1.pdf

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I
:i
•
ectroenceph.clin.Neurophysiol.
Suppl. 3, 21 (1953).
LSD 34 b
..._
liE_
_
....
"',
,,_(
EFFECT
OF
OF SOME
DRU(5
ON THE
EI.ECT.RICAL
THE
BRAIN
O_r THE
CONSCIOUS
CAT
P.B.
i:h,.am_.E'L
Et_Jand
Birmingham,
ACTIVITY
z
u'icaI activhy
has been recorded
from cortical
ubcortical regions in d_econscious cat using per-
ntlyimplantedclectrodes.
"i'heeffectsofarousaI
_rnla] waking
and sleeping
pilti.erlls
were
studied.
.]ilt_ine
sulphate
(2-:; mgm/Kg)
produced
large
;,m-
dc slow wave ;tcdvity (|escmiJih|g
,sleep rhythms)
"_ilfl_out cimngc
h/ belmviour;
physostigmhle
(0.5-1.0
mgCi_/'l_.g) produlcd
low vollage
l;t_t activity
of die
.alelI l.ype with_ut
inakinq/ile
;lililnill
nlorc
alert.
The
Atropine
or I-hyoscyamh_e
restored
tile spindle activ-
ity.
Amphetamine
and
d-lyser:4ic
acid
dic_hylamide
(l..S.1).
25) b_th
produced
elcitrical
activity
of the
alert
type in the
cons,
iotas animal.
This was accom-
partied
by a. alerting
of behaviour.
,\,Hphctamhle
also
increased
the rcslmnse
Io photic
sih|mlation,
rclordcd
from the visual cortex.
It abolixllcd
the spin-
die activity
of the cl_l('phalc
i,,d(: but not Ihat o[ the
(l,.l-VCiill i_ol(', nor did
barbilur;tte
;|n;|esthcsia.
;iculc
prepam_tiOl_S,
eil'('/'ks
of
,
[
of
["
l-hyos¢)';mdnc
(I-2 mgm/Kg)
were similar
Io
alropinc,
d-l.l)'oscyamine
and
ncostJgminc
;llropiuc
hi
it( tll.e
ll;e
illld
]-liyilscyiiltlill{2
ns
I)1"O-
it ab,disii
the spindle
activity
o[
I..S,I). 95 had J_ cJlcct on lhe
it abolJ.shcd
Slid
iil|'ol}illC
wlic;,cctive,
sostig.minc,
similar
{_ ilild
effects
licFVCiili
but
|]lc spil_dlc
I,.S.I).
ill
thch"
2,5
tl/tlS
acih'ity
differ
()l'
i);llqlJ[ttl'ilI.C
The
illl;I('s|hcsill,
iinll)hclillnJllc
add
])l'el_ilriil.ic,
(cni6plialc
being
isoK),
electrical
/hilllgeS
l'l'lllll
physostigmhle
dcpci_dc.nie
ted to the transient
blood pressure cilan_es,
on mesencephalic or spinal colmections. There is also a
better
ac|ivity
correlation
between
1)chaviour
and electric,d
with amplmt;mline
and I..S.J). 25
; ,:_n
there is
arotid in]ectio_;s o[ acetylcholinc
in these preps-
_q#ls produced
elleels similar
to tl_ose of physostJg-
but
illliJ,
of shorter
du|'atio||.
The spiudie
a(th'ity
of
anaestllcsiit
!,vils abolished
by physostig-
replaced
by continuous
rhythmic
activit),,
whh physostigminc
and atrophic.
It
is imssiblc
lhat
the site of action _11;m_phetamine
lllil}'
lie related
to tile
brain
stem reticuhir
activath_g
syslelll
O[ Magoun.
TABLE
• 4
I
¢
Drug
.;aviour
Elcctri/al
,kctiviiy
in
Bari_iturate
Spindle
Cims/h)us
Animal
I:HYSOSTIGMINE
Normal
retarded
,.n"
Lowamplitudc
/"Alerting."
A_tivity
51)indlc._rcplaccd
rhytimiic
activity
Slow
.\/tixily
Induced
,\tr_pinc
Abolished
Spimlle
,\(fixity
of
Spindle
.\<liviiv
of
I)y' l':lu(,phiile
Isoh"
Abolished
(:cl'v(,illl
l.s,_ld
.
,\boiishcd
ACETYLCii()LINE
................
slightly
I .....................
I
Spindlesrcplaced
,iV COlltilltiOtlS
AboIisi_cd
Abolished
Aboli_iled
_liast i ctivity
/b)'
(on t hn|o
USe
activity
(J_[tlinl
No efteel
No
effect
,\bolished
_
No
ctrect
I
AM1)HETAM
INE
Excited
I.ow amplitude
last activity.
"Alerting./'
*
I
_;_
L.S.D.
25
Exched
Iow
alni_lhudc[_ipi|ldles
abolished
No effect
No etfcct
No cttect
--.:'('_bstract No. I)
:
21

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