1953_liddell_1487_1.pdf

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Hethodrine (§65g)
M
328.1 Depression
M 381
Psychopathic states
M
328.6 A,
w4ety
hysteria
J
27
Blood
sugar
level
vl LSDNo.24 102A/R
(
Joy.) M 360
Sohop re
__ine
level
in A206
blood pl_,_,._.
LIDDELL_ D.W.,
WEYI-MALHERBE,H. (_
_osp., Wiekford,Essex)
The
effects
of Mothedrine
a_ Qf
IvserRic
acid
diethylamldo
m
ss
the bl
adre
•
i
i
J.Neurol.
Stg_8_AR¥
d-N=Methylamphetamine
hydrochloride (" methe-
drine
")
in doses of 40 to 60
rag.
and lysea-gic acid
diethylamide (L.S.D.)
in doses of
40
to 60
_.g.
were given by intravenous injection
to
patients
suffering from various
mental
disorders and their
clinical and biochemical effects studied.
After an initial phase of relaxation both drugs
produced an aggravation
of the clinical picture:
while depressive patients
became
more retarded
and depressed, or more agitated,
schizophrenic
patients showed signs of increased withdrawal and
temion
and an a,_.ntuation
of
catatonic
and
cataleptic features. Abreaction frequently occurred,
especially
in psychoneurotic
patients.
Rapid mood swings were sometimes observed
after the injection of L.S.D.
Methedrine did not
produce this
effect,
but it more readily provoked
hallucinations
in schizophrenic patients.
The biochemical studies consisted
in
the deter-
mination of the plasma adrenaline and blood sugar
concentrations.
The effects of both drugs on the
plasma adrenaline level were similar.
Three phases
could
be distinguished
after
the
injections:
an
initial rise of the adrenaline level, a drop
below
the
starting level, and finally a secondary rise. Indi-
vidual cases mainly differed in the speed
with which
these phases followed each other. Sometimes, and
especially after the injection of L.S.D., the adrenaline
level decreased
before
the initial rise
could be
observed.
When, however,
L.S.D. was
given
by
mouth, the initial increase of the adrenaline con-
centration was clearly evident.
A moderate increase of the
blood
sugar con-
ccntration
sometimes
followed
the injection of
methedrine,
but
the
effects
of L.S.D. on the blood
sugar concentration were
hardly
significant.
,,11

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