1953_rothlin_1486_1.pdf

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ell
( 75f)
(_75d)
M
76
@y ,xp.6_a
Behaviour
8momaly
(waltzing
mice)
eROTI_I,TN,
E. (Basle, Switzerland)
Xnfluonce
of ergot al_10ids 'and lyser_ic acid derivatives on an
_nherited
behaviou_
amo_ly
in
mice.
XIX lnternat.Physiol. Congress, Montreal
1953, Abstracts of Communications, p.948.
Both from the
clinical
and experimental point of view,
an
increas/ng
interest
for
the effects of ergot
alkaloids
end
lysergic
acid der/vatlves on the central nervous system can
be observed.
_/'hen
our laboratory
strain of
,,.ice
developed a hereditary behavio_
anomaly, characterized
by motor hyperexcitation,
we
therefore
seized the opp_
tunity
to investigate the action
of _e
ergot alkaloids on rids
part/cular phenomenon.
The film
shows
first the
typical
behaviour of mice with the
congenital
anomaly. In contrast
to
most
types
of waltzing mice described in
the
literature.
our
an/reals exhibit no defect of the
internal
ear or any:
anomaly
connected with lowered resistance.
The s/gns
of increased motor activity appear as soon as the an/reals
leave the nest and
start
circular movements.
The
same
animal
frequently
changes direction, speed
and
radius of
the rotation. Low motion pictures
make
evident that he
circular motion
is
the result of an extremely well coordin-
ated sequence of
movements
and is in no way due to any
kind of ataxia.
The naturally occurring alkaloid Ergotamine does
not
influence the activity of our waltzing mice. Hydrogenated
ergot
alkelo/ds, with
the
except/on of Dihydroergotamine,
however, proved to
be
very effective.
Doseso!
I-2
mg/kg of Hyderglne regularly produce dampening and
even complete inhibition of
the
motor overact/v/ty, but
without other symptoms of a genera] sedation. Inhibit/on
of the waltzing activity is also produced by the mono-and
di.ethylamide
of lysergic add, the basic
constituent
of
all
ergot
alkaloids. This result, however,
is
accomplished
in an absolutely different manner, the suppression
of
waltzing movements being the result
of
an
increased
gen-
eral excitatory state. These results bear an interesting
relationship to clinical experiments with ergot a|kalolds in
cases
of
psychomotor
excita_lon.
(Der Einfiuss
yon Mutter_orn_lka!oiden
und Lysorg_urederivatm_
eine erbliche
Verhaltensanomali_
bei
M_usen)
auf
I-2 mg/kg
Hyg verminderte oder
beseitigte
regeln_ssig die
motorische
Hyperaktivit_it
yon
Tanzm_usen, ohne
andere Symptome all-
gemeiner Sedation
hervorzurufen. Die
kreisenden Bewegungen wurden
auch
dutch
LSD
und
LAE gehemmt, jedoch Uber Erzeugung eines Erre-
gtu_gezustandes. @y und
DHE
h_ben keinen Einfluss
auf die
motorisc_
Aktivi_t
von
TanzJusen.
(Influence
des
alcalofdes
de
l'ergot et
des
d@riv@s
de
l'acide
lysergique sur une anomalie cong@nitale
du
comportement ches
des
souz"is)
i h 2 mg/kg d'Hyg
r_duit
ou aupprim8
r_guli_rement
l'hyper-
acti_ t_ motrice des souris valseuses sans
provoquer
d'autres
symptS_es de s_iation g_u@rale, Les mouvements de man_ge sont
@_lement
Ir_ib@s par LSD et LAE, mais
par
provocation d'un @tat
influence
g@n6ral d'excit_tion accentu@e. Gy et DHE n'ont aucune
sur l'activit@ motrice de souris dansantes.
,6.
(K527S)_J_/bh
_4

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