1954_sloane_1509_1.pdf

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m ._!_ct and file card
No. 6
.328
Psychotic
t
Ar e
ef__ect
M 377
M
360
Schizophrenia
M 328.1Depression
B
99.6
Cold pressor test
M
409
Rorschach tests etc.
A 222
Blood
oxygen
spectroscopic
_dmetry
_v.
of London) .
_i _choDhysiologlcal J.W.L. (Maudsley Hosp. & Inst. ofpsychoses:
DANE, B.,
DOUST,
PsychiataT,
investigations
in exp_rimontal
_4sults of the _xhibition of
d-ly_Qrglo
acid
diethylami_e
to
_ahiatric
patients. (Psychophysiologische
Untersuchungen
bei
e_Iperimentellen
Psychosen. Ergebnisse mit Verabreichung
von
L_D
an ps_hiatris_he
Patienten.)( Recherches psychologiques
ds
as des!_y_hoses
ex_rimentales:
r_sultats
de
I 'administra-
_ _n de di4thylamide
de
i' acide D-lysergiqae dans des cas
ps mhiatriques.)
J.ment.Sci. i00, 129 (1954).
Sunumy
i
_
:
d-lysergic add diethylamide
(L.S.D.-25)
was
#yen
to
Iz
healthy
controls,
Is
patients with
predominant
depression and
7
patients
with
schizo-
phren/a,
in an attempt to obtain comparative objectiv.,
c.-_imates
of some of the
psychological and physiological changes produced.
4o -_
of the tartrate was
given orally
and a few incidental
observations ready
of
the effects of larger
doses
up to
12o
7.
(2) Clinically
the
changes
resembled those
previously described and were
not gross. Accentuation
of pre-existing affect was commonest, with associated
]ability of mood, and
retention of
insight.
•(3)
There
was
no measurable
impairment of
memor
3- and concentration.
(4)Perceptual
changes were
uncommon
and
confined
to
unformed
x4su-,d
(I)
/
"_illumons in four
of the controls_
'tendency
under the drug.
Tests of eidetic
imagery showed
no eidetic
in
the
&pressives.
(5)Reversal
of
perspective
in
an ambiguous figure
was
unchanged
(6)
Qualitative
and quantitative
estimations
of
the Rorschach
showed no
sg_cant
cha_.
(7) An increased uptake of oxygen in
the
three schizophrenics
who
had
spirograms taken while under
the
drug
contrasted
with oxfly random changes in
_he controls.
Both groups
showed an increased
respiratory
rate.
(8) The response of the
blood
pressure to a pain stress showed no significant
variation
or,differential response
between
the
groups.
(9)
Spectroscopic oximetry
carried
out during this
pain
test and in the
"controlled
stress" of a word
association
test
showed significant
changes
however,
which were
interpreted
as
indicative
of
increased
autonomic
labiiity
h*
the
controls
and depressives
as contrasted with unmodified
functioning in
sehizophretlics.
It stz.md that o_aetry
had _e.*_cted a chan_e
u.:
apparent
in
the grosser
measures
of osdllometry.
....
.
,
(zo)
Similarly resting
o_n__tric
readinp
showed
a differential response
pattern between the sd_rol_ufmA_, the controls and the depressives.
The e_ciency score was very significantly raised in the depressive group,
_dae
reatestchange
g
beingmanifested
t_.
whose
in
illness
waspredominantly
Teactive.
If this fin,4i,_ be regardedasindicativeof improvedphysiological
_4mctionin_,
it couldbe con'elated four of thesix patientswith some
in
allevia-
tion
of thpir depression.
(zz) In conclusiem,it l_oved difficult to obtain valid differentiatingmeasures
of
clinically apparent
eh_n_.
The dimculty was felt to lie in the pancity of tests which were sufficiently
discriminative, and it
was
considered that an elaboration of _sen__tive hysto-
p
logical recordings would facilitate the study of experimental intoxications in
particular and of mental disease in general.
......
ZUSAM_ASSUNG:
II
gesunde Kontrollf_lle,
12
Patienten
mit De-
pressionszust_nden,
7
mit
Schizophrenie. Klinisch entspricht
die
LSD-Wirkn_ngfr_eren
Beschreib_mgen. Eine wenig intensive, Jedoc_
klinisch
noch
deutliehe
LSD-Wirkung war
dutch
psychologische,
Ereislaufs- und
A_mssfunktionsteste
schwer obJektivierbar.
Die
spektrcmetrisch best_mmte Reduktionszeit (RT)
des
Oxyh_o-
globins im
arterialisierten
KapT]larhlut (Nagelfalz)
war
je-
doch
bei
Gesunden
und
Depressiven
im
Gegensatz
zu Schizophrenen
als Zeichen grSsserer vegetativ-nervSser Labilit_t verl_ngert.
Entsprechend
wurde
der Einfluss
einer Apnoe von bestimmter
Dau-
er
auf die RT durch LSD bei Schizophrenen praktisch nicht ver-
Mndert, jedoch bei Depressiven signifikant verst_rkt. Bei Gesun-
den
war
die Verst_rkung
goring.
RESUME:
Le
LSD a _t_ administr_ _ Ii sujets-t_moins, _ 12
mala-
des
atteints de
d_pressions
et _
7
schizophr_nes. Les r_sultats
cliniques sont los
m_nes que
eeux d@J_ d@crits. En g_n_ral, des
modifications l_g@res, .mais
tout de rake
cliniquement visibles
....
.
dues
au LSD sc_t difficiles _ mettre en _vidence par des tes_
L
_onctionnels circulatoires et respiratoires.
Le
temps de r_duc-
1
tion
(T.R.)
de
l'cxyh/nnoglobine
d_termin_
par la spectrometric
dans
les capillaires sauguins ar_rialis_es (rainures sous-
_mgu& ss) _tait
prolong_
_hes les
t_oins
et
dans
les
d_pressions
mais
pas ches les sehizophr_nes: signes
d'augmentation
de la la_
bili_ neuro-v_g_tative. De
i
l'4-_luence
d'une
apnee
de
dur_e
d_termin_e
sur le
temps
de
_t,'l.on
(T.R.)
n'_tait
pas
modifi_e
par le LSD
chez
los
schizophr_nes,
mais nettement
renforo_e
dans
,
les dep_s_ions.
Chez les
t_oins
l'Influence _tait
moins
_one_¢_.
NKT/D,..
pilD,-._e,/_lT_ i_,$",el-
_um
(K .rs'_T_3,q
il

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