1954_welsh_1515_2.pdf

(79 KB) Pobierz
o_r_i and
1
r±le
oard
LSD
No.52
(§102a)
_
antagonism to serotonin (§725)
WELSH,
J.H.
(Biol.Labs.,Harvard
Univ.,
Cambridge, Mass.)
_[vdroxytrymtamines
neurohormone in the invertebrates.
a
Fea.P.n.162(1 4).
Recent evidence from several sources indicates
that 5-hydroxytryptamine (serotonin, enteramine)
is
a mediator of
nerve action
in
certain
of the
invertebrates. For example, it has
been
found to
excite the heart of the mollusc,
Venus mercenaria,
as
does
stimulation
of the visceral ganglion fol-
lowing
block
of the cholinergic inhibitor nerves.
Agents that block 5-hydroxytryptamine
also
abolish nervous excitation. Twarog (in press)
presents evidence that 5-hydroxytryptamine
is
the
normal
inhibitor of the anterior
byssus
re-
tractor muscle
of
Mytilus.
Paper chromatography
and bio-aseay have
been used
to identify
and
quantitate
the
acetylcholine
and
5-hydroxy-
tryptamine of the pooled eerebro-pleural, visceral
and pedal ganglia of
V.
mercenaria
and
those of
the gastropod
mollusc,
Busy_on canaliculatum.
In
Venus
ganglia the ratio of 5-hydroxytryptamine
to acetylcholine
is about 4:1 while in
Busyc,,_
ganglia it is about 1 :1. When Mytolon,
a neuro
muscular
blocking
agent, is used to block acetyl
choline inhibition of
the
Ven,s
heart the sensi
tivity
to 5-hydroxyt
ryptamine is unaltered. Wh,.,,
lysergic acid diethamide or ergot alkaloids are
used to block 5-hydroxytryptamine,
they do not
affect the response to acetylcholine. This indicates
that the antagonistic action of these 2 neuro-
hormones on the
Venus heart
is not due to compe-
tition for the same receptor substance. The ad-
dition of 5-hydroxytryptamine
to the
list
of
chemically-known
substances
that
are
produced
by
nerve cells and that act on effectors or other
neurons would appear proper. (Supported by
a
grant from the Natl.
Insts.
of Health, PHS.)
(Hydroxytryptamia|Ein Neurohormon
der
Wirbellosen)
Mytolon, eine
Substanz
mit curareartigerWirkung
blockierte
die Hemmwirkung
yon ACh am
Herzen
yon Venus mercena=ia, w_h=end
die
Ansprechbarkeit auf
Hydroxytryptam_n (Serotonin)nicht
ver-
Endert
wurde. LSD oder
Mutterkornalkaloideblockierten die
SerotoniD
wirk_,ng,Jedoch nicht die
ACh-Wirkung. _Betr. fr_here Arbeit
des
Verf.
_ber
die
LSD-Wirkung am gleichen Versuchsobjekt
siehe
LSD
_I, Rapport 3!/17J
(Hydroxytryptamine|une neurohormone des invert4br4s)
Mytolon, une substance _ effet curarisant, bloque l'action
inhibitrice de l'ACh sur le coeur de Venus mercenaria, mais ne
modifie pas la r4activit4 _ l'hydroxytryptamine(s4rotonine).Le
LSD ou
des alc.de l'ergot
de
seigle bloquemt l'action de la s4ro-
tonine, mais pas celle
de
I'ACh. [Quant aux %ravaux ant_-rieurs de
l'auteur
concernant l'effet du LSD sur le Coeur de Venus mercenaria,
v.
51,
appor
31/17.
w3
( 9oo)
_/Dr.Spi/Dr.Bs/bh
854
®3_

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin