1955_abramson_1530_1.pdf

(135 KB) Pobierz
Abstzact
VI ISD
and file
No.65
card
M 500
properties;
statistical
placebo
studies
KAUFMANN_MoRo,
evaluation;
(§102a)
ABR_SON,H.A.,
JARVIK,M°Eo,
KORNETSKY_Co
_ LEVINE_Ao,
WAGNER,
M°(DeptoMedo,Neurolo&
LvserEic
acid diethylamide
responses •
Psychiato_Mount
Sinai Hosp.New
York City)
(LSD-2_)"
IoPhysiological
and perceptual
J. Psycho 1.39,3 (1955 ).
On the basis
of
tests performed
on
26
non-psychotic,
intelligent
were given
from
one to three doses of lysergic acid diethylamide
micrograms,
and
100-225
micrograms),
and
to whom
adults, xvh,,
(zero,
25-7
_
in
a questionnaire,
vestigating
changes in physiological
and perceptual
phenomena,
was g,ven at
hourly intervals,
the
following
conclusions are drawn:
1. Symptoms most significantly related to the ingestion ot 50 micrograms
of the drug are (in order
of
decreasing significance)
: unsteadiness,
dream-like
feeling,
paraesthesias,
inner trembling,
pressure in ears, difficulty in
focusing
vision, weakness, lightness of limbs, lips drawn back as if smiling, dizziness,
drowsiness,
sensitivity of skin, and
peculiar
feeling of limbs. Less significant,
b;Jt probably
related, are: increased salivation,
increased appetite, sweating,
cold, and
fatigue.
2. Symptoms most significantly related to the ingestion of 100 micrograms
of the drug are (in order of decreasing significance):
things moving about
subjects,
unsteadiness,
paraesthesias,
weakness,
dream-like
feeling,
illness,
nausea, dizziness, sensitivity of skin, peculiar feeling of limbs, inner trembling,
sweating, lightness of limbs, blurred eyesight, difficulty
objects seeming
too tar away.
The less significant
s_mptoms
are:
feeling
of choking,
numbness
of lips,
in focusing
vision,
and
but probably
related
difficulty
in breathing,
quality
,t
the
cold, pressure in ears, and alteration
of shapes and colors.
3. There
may be
differences
in subjective
severity
and
symptoms
which
are reported
under
both drug
levels,
ttowever,
toms discriminate
greater percentage
between 50 and 109 micrograms
in that
of response under the high dose. These
nausea,
iunny
taste in mouth,
several symp-
they received a
are: feeling of
seeming
position
too
of
illness, heaviness of limbs,
tar away, and anxiety.
4.
There
is a significant
objects
correlation
of .83 between
the relative
symptoms, according to frequency of positive response, for the two
drug
groups.
5. The average number of symptoms, out of 47 suggested ones, under zero
dosage is about 3, under ....
_.,,,7_, micrograms
it is approximately
10-, and under
100-225 micrograms
it is about 14. "_be dit:ferences among the three groups
are all statistically
reliable at better than the .01 level of significance.
6.
The peak effect under zero dosage occurs in the first !2 hour, and that
of the low dose between 11,4 and 2_'i boors after the drug. The peak
for
the
wa (K7059) Nrr/DroBs/DroSpi/bh 155
!,,-ii
,],+-e ,_curs
1]_
hour>
_,t_¢'I
!IL< dI¢_.z
+rod the
eftect
are
i_ ]_,nizer
ba,,et]
la>tin}z
i:
..{
.I
• [
_!
tl,:_:, ior either
o{ the other
lzroup>.
The,e
-tatement,_
results
and
in,iivi,i_.:_}
variability
i> n<it considered
here.
7.
.90
"]'he numbe_
with
the
ot
,._: s_mptoms
he
reports
a subject
under
he
reporr_
the
hiffh
un¢]er
dose.
,_n _zroup
the ]ow
Alth,m_h
(t<_,e
correlates
the
_veralze
numi_er
number
croup.
relative
vivPIv
svmpt+,n3s
increases,
maintains
as high
]]is relative
as
.66
and
position
.60
between
within
the,;_.;i_
'3_i.,
.:
+
There
i, ;tl>o a relationship
subjects
position
under
This
indicate_
zero and under
low
a _airh
h_*b det_ree
and high doses
,_ predictability
of I.SD-25,
respec-
of the number
,,f
under
the p[aceb,_
T_.-p,_n..+*-
rt_
t!w ,t: tl_ _,n the b:t..,is _,_ the
I_tLT_
_er
t)!
responses
,'_ "llw r,.l_,tt_i_t_ ,.t re,l,,m_e_ to the questionnaire
J+-+-rere-r
'_lllllber
t).
t',;rf+.i;tri,+fl
;i-_ hi_:h
_ep+,rted
,,t
-_nt;,t,+m_
t,_ he utlrcl:,u',i
t-
,tt
t_o
.77
wa.
>epar,_re
o[_ramed
te_tmlZs
in
,)J;
,.x
ll_i)t_'l-
"lhe
numi,er
_,itlxct
has been found hi_zh.
c_mparm¢
the Saltle
b_d5
weiKht
directi<m.
the
total
u_der
dos_tge.
have
:_-ported
,,r
n_t
a_:d t}_...ubiect's
be_'n sh_xvn
r_+l:_tr,t m the expec_e,I
(LSD: I_re communication. Modifications
fonctions
physiologiques)
de la perception
i
et des
26 sujets adultes sains ont re_u 25 _ 225 _ de LSD par
voie buccale et des placebos (eau)o Les r_ponses _ _ points d'un
questionnaire
concernant les modifications
des fonctions v_g_tatlves
et des perceptions aprBs LSD so_t statistiquement
analys_es. D'aprBs
les r_sultats ainsi obtenus, les investigations
ant_rieures sur le
LSD chez des sujets sains semblent n_cessiter une r_valuation
par
l'emplol de placebos. Sans l'emploi de placebos, une _valuation
v_ridique des effets du LSD est impossible. Les questions ayant
obtenu une r_ponse positive se rapportent, en g@n_ral, _ des fonctlons
autonomes, partictuliBrement _ celles qui se trouvent alt_r_es_n_
des _tats d'anxi_t@. Les sympt6mes observes apr_s administration
de placebos sont, en g_n_ral, de nature d_pressiveo
(LSD: I. Ver_nderungen
Funktionen)
der Wahrnehmung
und der physiologischen
26 geistig gesunde Erwachsene erhielten 25-225_ LSD
oral
bzw. Placebos (Wasser)o Die Ant_orten auf 47 Punkte eines Frago_gem_
betroVer_nderungen
de_ vegeta_iven Funktionen und der W_brneh_
nach LSD wurden statistisch analysierto Nach dem Ergebnis schelm_n
frtthere Untersuchungen
i
iber LSD bei Gesunden der Nachprt_fu_g unter
Anwendung von Placebos zu bedt_rfen. Ohne eine solche ist eine mu-
verl_ssige Auswertung
der LSD-Wirkung unmSglich@ Die positiv beant-
worteten Fragen betrafen meist autonome Funktlonen und zwar besonder_
solche, welche bei _ng_tlichen Affekten alteriert sind° Die Symptom_
nach Placeboverabreichung
waren meist depressiver Natur_

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin