1955_evarts_4040_1.pdf

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No.155
(§lO_a)
Effects of physiological
M
500
subnormality
visual system
effect>
and LSD
on posl-
,
!_=?=:,
telanic potentiation of lateral geni_ulate potentials.
EDWAm) V. EVARTS AND JOaN R. HUGtfES (intro-
duced by W._E H. MARSltALL). Natl. Inst. of
Mental Health, Natl. Insts, of Health,
Bethesda,
Md.
In a previous
(Proc.
ilarity
communication,
Evarts
and Marshall
a"
Am. Neurol. A.,
z955)
between
the excitability
demonstrated
a sim-
cycles of gci_ic/i]ale
soma
responses to paired optic-nerve
shocks during
physiohJgical subnormality
and
subnormality
induced
by lysergic acid diethylamide
(LSD). In lhc present
study, the degree of post-tetanic t_tentiation
(PTt'i of
geniculate
soma responses is compared under
these
two forms of subnormality.
The geniculate soma re
spon_ to
single
shock to the contralateral
optic nerve
was recorded in nembutalized
or decerebrate cats. In
nembutalized
animals, LSD (oA6 mg/kg i.v.) produced
a marked decrease (up to 9o%) in the amplitude ,d the
soma response; a 2o-sec. tetanus of maximal shCwks
,'tt
Soo/see. applied to the optic nerve during
I.SI}-
induced
depression v,as
iot[o_ed
t,y an increase in _ma
aml)htude
up
to 700%.
Similar
potentiation
was
seen
in decerebrate
preparations,
though the quantity
of
LSD required to produce equivalent decrease in soma
amplitude was 2- 3 times
greater.
In other experiments,
physiological subnormality
was induced by preceding
each single test shock by a volley
of
r2
shocks (400/
see.). Under these conditions,
PTP was seen for a
period
of several
minutes
followinga
2o-sec.tetanus
of
maximum shocks at 5oo/sec.
It
is concluded that both
physiological
subnormality
and subnormality
imluced
by LSD lead to an enlargement
of the subliminal
fringe,
and that such an enlargement
is associated
with a high degree
of
PTP.
_
(K
8494)
lll_/bh
456
_)G?,

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