1956_abramson_4032_1.pdf

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VI
ISD No. 147 (§102a)
(§91c)
H.A.,
acid
JARVIK,
M.E.,
Z 355 tolerance
M
350
psychoses,
GORIN, M.H., HIRSCH,
Spring
Harbor]Long
Tolerance
xvII.
theory
M.W.
Island
develop-
(1956)
of
N.Y.)
BOL
_R_SON,
(The
_ser_ic
_ntr
Biological
Laboratory,
diethylamide
Cold
(LSD-25):
and
its relationshi
_ to a theory of osych6sis.
•
J.Psychol.
A1, "81
F.
_U,MMARY
AND
CONCLUSIONS
1.
were
The
Three
tested
response
and
subjects with considerable
with LSD-25
on six and
to a questionnaire
sixth
days
an
increase
experience
in LSD-25
three consecutive
days,
rapidly
from
appeared.
Five
days
experiments
respectively.
On
sixth
the
diminished
day to day.
after
the fifth
day the response to 100 micrograms
of LSD-25
by Subject .4 was not as
great as on the first day but was
greater
than on the other days.
The low-
est number of responses resembled
a 25-microgram
response.
The symp-
toms reported
at that time were
appeared
less frequently.
2.
Subjects
B
and
C
received
more
typical
of high
dose symptoms
but
increasing
doses of LSD-25
on successive
days, beginning
with doses
of
five micrograms
and gradually
increasing
to
100 and 75 micrograms,
respectively.
Subjects exhibited marked tolerance.
Their responses to the highest doses we:re less than their usual responses to
a 25-microgram
3.
Subject
dose of LSD-25.
C
demonstrated
tolerance
to
100
micrograms
of BOL-148
if any,
of tile
given twice daily for two successive
tolerance to 25 micrograms of LSD-25
4.
'
All
of the
foregoing
data
were
days, but showed only slight,
given the
following
day.
co6rdinated
with
The
the
theory
mechanism
development
and loss of tolerance
to LSD-25.
has four essential steps:
a.
LSD-25
interacts with a neuro--metabolic
toms, and becomes modified,
reaction and as long as
LE
served.
b. LE
splits
are eliminated.
c.
d.
When
With
suggested
s_.mp-
system,
E,
to cause
and is converted
to
LE.
This is a reve_ihle
is present ,;ome LSD-25
reaction might be ,_b-
tolerance
factor)
and other
products
which
into ET (the
Er comes into contact with LSD-25
it forms
LE.
the loss of u_lerance in time, ET is eliminated
as a decom-
or excretit_n.
The
los,; of ET will
== k4t
and
x
is the amount
of ET lost
follow
the equation:
A
log ---
A--x
po_,ition product
where
,4
is the initial
amount
of
lLr
present
in
time.
t.
5. The
theory
developed was
discussed
relation
in
tothe dataobtained.
Application of
the
formula
to the
data demonstrated
the
relationship be-
tween the predicted effective dose of LSD-25 and the effective dose found.
Further
experimentation
was
suggested
to
verify
certain
predictions.
_
'_
_f_'_+_
.
S
1
6. The
theory for development
and
loss of
tolerance to
LSD-25 was
adapted
to
a
theory
pertaining to the nature of schizophrenia. A substance
P,
analogous to LSD-25, was suggested as giving rise to
the
mechanisms
of tolerance which are
either
lost or altered during clinically psychotic re-
actions.
7.
It was proposed that both
the
P
substance
and
anti-P
substances (E¢)
should
be
sought
in the urines of clinically
schizophrenic
patients, and
that
anti-P
substances might
also
be found in non-schizophrenic urines.
" _
_
-
ii
_ _
(LSD: XVII. Auftreten von Gew_hnung,
Theorie der Psychose).
Beziehungen
zu einer
Untersuchungen
an 3 gesunden Vp. ergaben, dass bei Verabfol-
gung yon ISD an aufeinanderfolgenden
Tagen deutliche Gewb%-
nung auftritt. Eine Vp. zeigte Toleranz gegen_ber BOL (2x
tgl. 100_w_hrend
2 Tagen), aber eine h_chstens geringf_ige
gegenh_oe#LSD
_25 _) am darauffolgenden
Tag. Vff. entMickeln
eine Hypothese _ber das Auftreten und Verschwinden
der Ge-
wb%nung an L_D und begrthqden darauf eine Theori@
h"oer das
Wesen der Schizophrenle.
_ISBELL et al., ISD Nr. 82, Rapport
42/12 berichteten _ber Gewbqqnung an LSD ._
_
_'°
i
(ED
8671)
NKT/Dr.Spi/ev
456
_
÷

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