Biochemistry 8th Edition - W. H. Freeman. Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer (2015).pdf

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Biochemistry
EIGHTH EDITION
Jeremy M. Berg
John L. Tymoczko
Gregory J. Gatto, Jr.
Lubert Stryer
Publisher:
Kate Ahr Parker
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Denise Showers with Sherrill Redd
Manuscript Editors:
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Cover and Interior Design:
Vicki Tomaselli
Illustrations:
Jeremy Berg with Network Graphics, Gregory J. Gatto, Jr.
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Janice Donnola
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Aptara
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, Inc.
Printing and Binding:
RR Donnelley
Library of Congress Control Number:
2014950359
Gregory J. Gatto, Jr., is an employee of GlaxoSmithKline (GSK), which has not supported
or funded this work in any way. Any views expressed herein do not necessarily represent
the views of GSK.
ISBN-13: 978-1-4641-2610-9
ISBN-10: 1-4641-2610-0
©2015, 2012, 2007, 2002 by W. H. Freeman and Company; © 1995, 1988, 1981, 1975 by
Lubert Stryer
All rights reserved
Printed in the United States of America
First printing
W. H. Freeman and Company
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New York, NY 10010
www.whfreeman.com
To our teachers and our students
ABOUT THE AUTHORS
JEREMY M. BERG
received his B.S. and M.S.
degrees in Chemistry from Stanford (where he did
research with Keith Hodgson and Lubert Stryer)
and his Ph.D. in Chemistry from Harvard with
Richard Holm. He then completed a postdoctoral
fellowship with Carl Pabo in Biophysics at Johns
Hopkins University School of Medicine. He was an
Assistant Professor in the Department of Chemistry
at Johns Hopkins from 1986 to 1990. He then moved
to Johns Hopkins University School of Medicine
as Professor and Director of the Department of
Biophysics and Biophysical Chemistry, where he
remained until 2003. He then became Director of
the National Institute of General Medical Sciences
at the National Institutes of Health. In 2011, he
moved to the University of Pittsburgh where he
is now Professor of Computational and Systems
Biology and Pittsburgh Foundation Professor and
Director of the Institute for Personalized Medicine.
He served as President of the American Society for
Biochemistry and Molecular Biology from 2011–2013.
He is a Fellow of the American Association for the
Advancement of Science and a member of the Institute
of Medicine of the National Academy of Sciences.
He received the American Chemical Society Award
in Pure Chemistry (1994) and the Eli Lilly Award
for Fundamental Research in Biological Chemistry
(1995), was named Maryland Outstanding Young
Scientist of the Year (1995), received the Harrison
Howe Award (1997), and received public service
awards from the Biophysical Society, the American
Society for Biochemistry and Molecular Biology, the
American Chemical Society, and the American Society
for Cell Biology. He also received numerous teaching
awards, including the W. Barry Wood Teaching
Award (selected by medical students), the Graduate
Student Teaching Award, and the Professor’s Teaching
Award for the Preclinical Sciences. He is coauthor,
with Stephen J. Lippard, of the textbook
Principles of
Bioinorganic Chemistry.
Molecular Biology of Cancer, and Exercise
Biochemistry and coteaches an introductory course,
Energy Flow in Biological Systems. Professor
Tymoczko received his B.A. from the University of
Chicago in 1970 and his Ph.D. in Biochemistry from
the University of Chicago with Shutsung Liao at the
Ben May Institute for Cancer Research. He then had
a postdoctoral position with Hewson Swift of the
Department of Biology at the University of Chicago.
The focus of his research has been on steroid recep-
tors, ribonucleoprotein particles, and proteolytic
processing enzymes.
GREGORY J. GATTO, JR.
,
received his A.B.
degree in Chemistry from Princeton University,
where he worked with Martin F. Semmelhack and
was awarded the Everett S. Wallis Prize in Organic
Chemistry. In 2003, he received his M.D. and Ph.D.
degrees from the Johns Hopkins University School
of Medicine, where he studied the structural biology
of peroxisomal targeting signal recognition with
Jeremy M. Berg and received the Michael A. Shanoff
Young Investigator Research Award. He completed a
postdoctoral fellowship in 2006 with Christopher T.
Walsh at Harvard Medical School, where he studied
the biosynthesis of the macrolide immunosuppres-
sants. He is currently a Senior Scientific Investigator
in the Heart Failure Discovery Performance Unit at
GlaxoSmithKline.
LUBERT STRYER
is Winzer Professor of Cell
Biology, Emeritus, in the School of Medicine and
Professor of Neurobiology, Emeritus, at Stanford
University, where he has been on the faculty
since 1976. He received his M.D. from Harvard
Medical School. Professor Stryer has received many
awards for his research on the interplay of light and
life, including the Eli Lilly Award for Fundamental
Research in Biological Chemistry, the Distinguished
Inventors Award of the Intellectual Property Owners’
Association, and election to the National Academy of
Sciences and the American Philosophical Society. He
was awarded the National Medal of Science in 2006.
The publication of his first edition of
Biochemistry
in
1975 transformed the teaching of biochemistry.
JOHN L. TYMOCZKO
is Towsley Professor
of Biology at Carleton College, where he has taught
since 1976. He currently teaches Biochemistry,
Biochemistry Laboratory, Oncogenes and the
iv
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